Abstract: Aiming at the high incidence problem of rock burst disasters in isolated island working face in irregular fault coal pillar area, the 7439 isolated island working face of Sanhejian Coal Mine is taken as the engineering background, and the stress evolution characteristics and microseismic activity laws of surrounding rock masses in the mining process of the working face are studied by FLAC^3D numerical simulation and microseismic monitoring.The results show that the 7439 working face is in a multi-side free state, and is close to the irregular fault coal pillar area, with a high risk of rock burst in a whole.The track roadway adjacent to the F₇ fault coal pillar area, the intersection right angle area between the working face and the transportation roadway, and the protective coal pillar area near the main roadway during the mining period of the working face have significant stress concentration, which are the key prevention and control areas of rock burst.Numerical simulation and field microseismic monitoring results have good consistency.The research results provide strong scientific and technological support for the prevention and control of mine dynamic disasters under similar conditions.